Introduction – Company Background
GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.
With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.
With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.
From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.
At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.
By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.
Core Strengths in Insole Manufacturing
At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.
Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.
We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.
With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.
Customization & OEM/ODM Flexibility
GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.
Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.
With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.
Quality Assurance & Certifications
Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.
We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.
Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.
ESG-Oriented Sustainable Production
At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.
To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.
We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.
Let’s Build Your Next Insole Success Together
Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.
From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.
Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.
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Taiwan insole ODM manufacturing factory for global brands
Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.
With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Thailand ODM expert for comfort products
Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.
We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Vietnam graphene sports insole ODM
At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Cushion insole OEM solution Vietnam
📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Indonesia OEM/ODM hybrid insole services
A specimen of P. squamosissimus caught in the Chavantes reservoir (São Paulo state): originally from the North region, it may be competing with and contributing to a decline in the population of native species. However, it has become a key fishing resource in much of the country. Credit: Edmir Daniel Carvalho/CAUNESP In São Paulo, Brazil, the Silver croaker, an invasive species, has become the predominant fish in the Jaguari reservoir and surrounding rivers, significantly diminishing the diversity of native fish species. Despite its economic importance, controlling its population poses significant ecological and legal challenges. The Silver croaker (Plagioscion squamosissimus), also known as corvina or pescada-branca in Portuguese, is native to the Amazon and is likely responsible for the significant decline in the diversity of native species in the Jaguari Reservoir, Jaguari River, and Rio do Peixe. These water bodies are integral components of the Cantareira Water Production System and the Paraíba do Sul Basin, located in São Paulo state, Brazil. As a top predator in the food network, the invader has negatively affected local biodiversity by bringing about detrimental changes to its taxonomic, functional and phylogenetic structure, according to a study published in the journal Biological Invasions by researchers at São Paulo State University (UNESP). They analyzed fish monitoring data collected by power utility CESP (Companhia Energética de São Paulo), which has recorded the presence of the species in the reservoir since 2001. The data analyzed is for a period ending in 2016. In no more than ten years, P. squamosissimus has become the most abundant fish species in the reservoir. Research and Monitoring Efforts “Although this predator is widely distributed in hydroelectric dam reservoirs throughout Brazil, its potential effects on native species had never been studied before. Our analysis highlights considerable losses to fish species diversity in the region,” said Aymar Orlandi Neto, first author of the article. Conducted at the Ilha Solteira School of Engineering (FEIS-UNESP), the study was part of his PhD research at the Botucatu Institute of Biosciences (IBB-UNESP) with a scholarship from FAPESP. Some of the results were obtained while he was doing research at the University of Valencia in Spain with a scholarship from FAPESP. CESP does this monitoring of fauna to comply with environmental licensing rules for operation of the dam and power plant enforced by IBAMA, the main federal environmental agency. Every four months its technicians install nets at predetermined locations in the reservoir (between Jacareí and São José dos Campos) and on the Peixe and Jaguari, identify the species caught, and estimate their abundance. Effects on Native Predators “We analyzed 15 years of monitoring data and found the abundance of native predators, particularly the Thin dogfish (Oligosarcus hepsetus), to have declined significantly as P. squamosissimus preyed on smaller fish and became more abundant,” said Igor Paiva Ramos last author of the article and a professor at FEIS-UNESP. However, it is not possible to tell from the available data whether the decline of O. hepsetus was due to indirect competition, since both this species and the invader may prey on the same fish. Another possibility is that P. squamosissimus, which can reach 80 cm, preyed on O. hepsetus, which is much smaller (30 cm as an adult). The former typically inhabits standing water bodies, such as lakes, and has thrived in the reservoir, whereas O. hepsetus, the native predator, prefers running water. Economic Impact Invader species are a global problem and occur in environments of all kinds, on land and in water. In Brazil, the annual damage caused by non-native animals, plants, and microorganisms has been estimated at BRL 15 billion (now about USD 2.9 billion). The figure is from the Thematic Report on Invasive Exotic Species, Biodiversity and Ecosystem Services, launched in March by the Brazilian Platform on Biodiversity and Ecosystem Services (BPBES), which is supported by FAPESP via its Research Program on Biodiversity Characterization, Conservation, Restoration and Sustainable Use (BIOTA-FAPESP). In the article on the UNESP study, the researchers stress that other introduced species appear in the records for the Jaguari reservoir, including the Peacock bass (Cichla spp.), also native to the Amazon, and Oreochromis niloticus and Coptodon rendalli, both of which are tilapias and originally from Africa, but their numbers are very small, reinforcing the conclusion that native diversity has dwindled due to P. squamosissimus. The diversity loss observed by the authors applies to all three dimensions considered when this type of impact is assessed – taxonomic, functional and phylogenetic. Species richness losses during the period analyzed were noted, alongside the substitution of many rare specialist species by a few generalists, and significant differences were found in species composition and abundance in the local fish community, with entire evolutionary groups disappearing. Management Challenges There are no simple solutions to the problem. The species is seen as a key fishing resource for both subsistence and sport. Eradicating it could cause social problems. “The species has become very common throughout Brazil. It replaces native species and now plays a very important social role in local economies,” Ramos said. Nevertheless, he proposed measures similar to those taken in other countries to deal with invader species. One such measure would be to permit hunting of this species throughout the year without size limits or a ban during the reproductive period, with the aim of eradicating it or at least reducing its abundance. However, federal and state laws restrict fishing not just of native species, which is quite right, but also of invasive species to some extent. “This ends up perpetuating the species that are harmful to local fauna,” Orlandi Neto said. Ramos pointed out that the eradication of invaders does not necessarily lead to a return of the natives. “We don’t know whether another invader will take the place of P. squamosissimus if it’s removed. The environment has been modified to such an extent that it may no longer be suitable for former inhabitants,” he said. Reference: “Long-term impact of an invasive predator on the diversity of fish assemblages in a neotropical reservoir” by Aymar Orlandi Neto, Danilo Caneppele, Hugo Marques, João Henrique Pinheiro Dias, Juan Antonio Balbuena, Claudio de Oliveira and Igor Paiva Ramos, 14 February 2024, Biological Invasions. DOI: 10.1007/s10530-023-03243-9
This image shows a brain organoid with optic cups. Credit: Elke Gabriel Human induced pluripotent stem cells (iPSCs) can be used to generate brain organoids containing an eye structure called the optic cup, according to a study published on August 17, 2021, in the journal Cell Stem Cell. The organoids spontaneously developed bilaterally symmetric optic cups from the front of the brain-like region, demonstrating the intrinsic self-patterning ability of iPSCs in a highly complex biological process. “Our work highlights the remarkable ability of brain organoids to generate primitive sensory structures that are light sensitive and harbor cell types similar to those found in the body,” says senior study author Jay Gopalakrishnan of University Hospital Düsseldorf. “These organoids can help to study brain-eye interactions during embryo development, model congenital retinal disorders, and generate patient-specific retinal cell types for personalized drug testing and transplantation therapies.” Many aspects of human brain development and diseases can be studied using 3D brain organoids derived from pluripotent stem cells, which can give rise to all cell types in the body. Researchers previously used human embryonic stem cells to generate the optic cup, which gives rise to the retina—the light-sensitive layer of tissue at the back of the eye. Another study demonstrated that optic-cup-like structures can be generated from iPSCs, which are derived from adult cells that have been genetically reprogrammed back into an embryonic-like pluripotent state. This graphical abstract shows how optical vesicle brain organoids are developed. Credit: Gabriel et al./Cell Stem Cell In the past, the production of optic cups from pluripotent stem cells focused on generating the pure retina. Until now, optic cups and other 3D retinal structures had not been functionally integrated into brain organoids. To achieve this feat, Gopalakrishnan and his team modified a protocol they previously developed for turning iPSCs into neural tissue. The human brain organoids formed optic cups, which appeared as early as 30 days and matured as visible structures within 50 days. This time frame parallels that of retinal development in the human embryo and could make certain types of developmental neurobiology experiments more efficient. Across 16 independent batches from four iPSC donors, the researchers generated 314 brain organoids, 72% of which formed optic cups, showing that the method is reproducible. These structures contained diverse retinal cell types, which formed electrically active neuronal networks that responded to light. The optic cup brain organoids also contained lens and corneal tissue and exhibited retinal connectivity to brain regions. “In the mammalian brain, nerve fibers of retinal ganglion cells reach out to connect with their brain targets, an aspect that has never before been shown in an in vitro system,” Gopalakrishnan says. In future studies, they plan to develop strategies to keep the optic cups viable for long time periods, using them to investigate mechanisms that cause retinal disorders. Reference: “Human brain organoids assemble functionally integrated bilateral optic vesicles” byElke Gabriel, Walid Albanna, Giovanni Pasquini, Anand Ramani, Natasa Josipovic, Aruljothi Mariappan, Friedrich Schinzel, Celeste M. Karch, Guobin Bao, Marco Gottardo, Ata Alp Suren, Jürgen Hescheler, Kerstin Nagel-Wolfrum, Veronica Persico, Silvio O. Rizzoli, Janine Altmüller, Maria Giovanna Riparbelli, Giuliano Callaini, Olivier Goureau, Argyris Papantonis, Volker Busskamp, Toni Schneider and Jay Gopalakrishnan, 17 August 2021, Cell Stem Cell. DOI: 10.1016/j.stem.2021.07.010
Research shows that mice avoid previously victorious opponents due to brain responses triggered by oxytocin, highlighting a biological basis for social learning and avoidance behaviors. Credit: SciTechDaily.com Findings may offer insight into social disorders like autism. Like humans, mice live in complex social groups, fight over territory and mates, and learn when it is safer to avoid certain opponents. After losing even a brief fight, the defeated animals will flee from the mice that hurt them for weeks afterward, a new study shows. Led by researchers at NYU Grossman School of Medicine, the study reveals that such “retreating behavior” is influenced by a distinct area on the underside of the hypothalamus, a part of the brain that controls hunger, sleep, and levels of many hormones. The team had previously found that this special region, called the anterior ventrolateral part of the ventromedial hypothalamus (aVMHvl), helps rodents defend themselves against bullies’ attacks. Here, the authors further identified a central role of the area to drive longer-lasting avoidance after being defeated. The Role of Oxytocin in Social Learning The study showed that when rival mice first meet, scent information about opponents is not strong enough to activate aVMHvl cells to prompt a retreat. Once a fight begins, however, pain (such as from getting bitten) triggers the release of the “cuddle hormone” oxytocin. While this signal has long been linked with parenting and attraction, in this case it binds to oxytocin receptors on aVMHvl cells and signals danger. This process links pain signals to the opponent’s scent so the next time the aggressor approaches, its smell alone encourages the bullied mouse to stay away, say the study authors. “Our findings provide new insight into how oxytocin within the hypothalamus drives learning from traumatic social experiences,” said study lead author Takuya Osakada, PhD. “While the hormone is often associated with positive behaviors like caregiving, our study highlights its key role in social conflict,” adds Osakada, a postdoctoral fellow in the Departments of Psychiatry and Neuroscience and Physiology at NYU Langone Health. Implications for Human Social Disorders The study team, while cautioning that mice share a lot of brain chemistry with people but are not the same, says previous research has shown similar “retreat” behavior following social defeat in many species including humans. In addition, past studies in children have linked the experience of being bullied to increased social isolation and school absences. Osakada notes that while previous research had examined rodent behavior over time after experiencing repeated defeats, the new study, publishing online today (January 24) in the journal Nature, is the first to explore rapid social learning that occurs immediately after losing a fight. For the research, the study team observed hundreds of mice that were exposed to a rival for 10 minutes before being separated. They also measured the animals’ brain activity before and after a conflict. The results showed that 24 hours after losing a single fight, social interaction dropped down to just 20% of pre-defeat levels. In addition, the findings revealed that pain prompted the immediate activation of oxytocin-releasing brain cells located right next to the aVMHvl. To further examine the role of the aVMHvl in social avoidance, the researchers prevented receptors on these cells from binding to oxytocin. They found that rodents with blocked oxytocin receptors were less likely to retreat from their aggressor in later encounters. Meanwhile, when the team instead artificially activated aVMHvl cells, animals kept to themselves even if they had not lost a fight. “Now that we have a better understanding of critical forces behind social avoidance, researchers can start exploring ways to harness oxytocin to treat disorders that affect social skills, such as autism, social anxiety, and attention-deficit hyperactivity disorder,” said study senior author Dayu Lin, PhD. Lin is a professor in the Departments of Psychiatry and Neuroscience and Physiology at NYU Langone, as well as a member of its Neuroscience Institute. That said, Lin cautions that while the team connected the aVMHvl to social avoidance, they found no such link to another behavior exhibited by defeated mice — freezing up in the face of conflict. As a result, researchers say additional brain systems are likely involved in defeat behavior, and understanding such systems is essential before developing oxytocin-based therapies for human social disorders. The study team next plans to examine whether the newly uncovered aVMHvl mechanism may also be involved in behaviors that rodents use to establish their social hierarchy under more natural conditions, instead of during the contrived scenario from the initial experiment. Reference: “A dedicated hypothalamic oxytocin circuit controls aversive social learning” by Takuya Osakada, Rongzhen Yan, Yiwen Jiang, Dongyu Wei, Rina Tabuchi, Bing Dai, Xiaohan Wang, Gavin Zhao, Clara Xi Wang, Jing-Jing Liu, Richard W. Tsien, Adam C. Mar and Dayu Lin, 24 January 2024, Nature. DOI: 10.1038/s41586-023-06958-w Funding for the study was provided by National Institutes of Health grants U19NS107616, R01MH101377, R01MH124927, and R01HD092596. Further funding was provided by the Mathers Foundation, the Vulnerable Brain Project, the Uehara Memorial Foundation, the JSPS Overseas Research Fellowship, and the Osamu Hayaishi Memorial Scholarship. In addition to Osakada and Lin, other NYU Langone researchers involved in the study were Rongzhen Yan, PhD; Yiwen Jiang, MS; Dongyu Wei, PhD; Rina Tabuchi; Bing Dai, BS; Xiaohan Wang, PhD; Richard Tsien, PhD; and Adam Mar, PhD.
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