Introduction – Company Background
GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.
With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.
With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.
From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.
At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.
By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.
Core Strengths in Insole Manufacturing
At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.
Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.
We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.
With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.
Customization & OEM/ODM Flexibility
GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.
Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.
With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.
Quality Assurance & Certifications
Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.
We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.
Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.
ESG-Oriented Sustainable Production
At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.
To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.
We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.
Let’s Build Your Next Insole Success Together
Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.
From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.
Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.
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Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.
With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Soft-touch pillow OEM manufacturing factory in Taiwan
Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.
We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Cushion insole OEM manufacturing facility Taiwan
At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Indonesia sustainable material ODM solutions
📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Arch support insole OEM from Vietnam
The study demonstrated that the reproductive system influences overall health and aging. The Study Identified the Negative Consequences of Disrupting Meiosis A new study in an animal model of aging indicates a potential reason for why women who have early menopause or other genetic conditions affecting the reproductive system are more prone to develop cardiovascular disease, diabetes, and dementia. The new study, led by researchers from the University of Pittsburgh and UPMC and published in the journal Aging Cell, found that disrupting a process called meiosis in C. elegans reproductive cells caused a decline in the worms’ health and triggered an accelerated aging gene signature similar to that of aging humans. “This study is exciting because it’s the first direct evidence that manipulating the health of reproductive cells leads to premature aging and a decline in healthspan,” said senior author Arjumand Ghazi, Ph.D., associate professor of pediatrics, developmental biology, and cell biology and physiology at Pitt and UPMC Children’s Hospital of Pittsburgh. “The implications of this finding are profound: It suggests that the status of the reproductive system is important not simply to produce children, but also for overall health.” A young C. elegans adult glowing green where a protein has been linked to a fluorescent tag and filled with soon-to-be-laid eggs that appear as dark spheres in the mother’s body. Disruption of meiosis, a process on which the creation of these eggs depends, shortens the animal’s entire lifespan and accelerates its aging. Credit: Scott Keith & Arjumand Ghazi Meiosis Disruption and Accelerated Aging in C. elegans While the consequences of aging on fertility are well known, research in the past two decades has started to show that reproductive fitness also has an impact on human aging and health. The issue is that it is difficult to directly examine this kind of cause and effect in humans. Ghazi and her colleagues then turned to the Caenorhabditis elegans, a microscopic nematode worm that is an ideal system for aging research due to its short lifetime (three weeks from birth to death) and shared genetic pathways with humans. Arjumand Ghazi, Ph.D., associate professor of pediatrics, developmental biology, and cell biology and physiology at the University of Pittsburgh and UPMC Children’s Hospital of Pittsburgh. Credit: UPMC The researchers studied meiosis, a kind of cell division present in all animals from yeast to humans that happens exclusively in cells destined to produce sperm or eggs. They discovered that animals with mutations in meiosis genes had shorter lives than their non-mutated counterparts. The mutants also had worse overall health ratings, including premature reductions in mobility, muscular function, and memory. “The exciting part of this healthspan work was that these animals also showed signs of disrupted protein homeostasis,” said Ghazi. “Disruption to the balance of proteins inside cells is at the heart of age-related neurodegenerative diseases, like Alzheimer’s disease.” When the researchers improved protein homeostasis in the worms, some loss of lifespan was prevented. These findings point to disrupted proteostasis as a key mechanism linking reproductive health and aging. Premature Aging Gene Signatures Found in Mutants Next, the team looked at gene expression changes in C. elegans. At day 1 of adulthood, meiosis mutants expressed genes that were remarkably similar to those normal worms wouldn’t express until day 10. “In human terms, it’s like someone in their early 20s having the physical appearance, physiology, and gene signatures of a 70-year-old,” explained Ghazi. “Messing with meiosis has dramatic effects on healthspan and accelerates aging in C. elegans.” Many of the same genes control aging in worms and humans. So the researchers asked if the meiosis mutants’ gene signature had any similarities with the genes of aging humans. They found that this was, indeed, the case — a notable finding as it suggests that disrupting the reproductive system may produce similar changes from worms to humans. Since C. elegans can be used to make fundamental discoveries not possible in humans and more complex systems, this discovery opens up great possibilities for understanding how the reproductive system shapes aging, said Ghazi. She is now planning to partner with UPMC Magee-Womens Hospital and Magee-Womens Research Institute to further probe this question in human patients who, due to genetic disease, undergo extremely premature menopause and exhibit complications such as heart disease, autoimmune disorders, and osteoporosis. “Informed by our work in C. elegans, we want to develop a panel of age-related genes and use this to screen patients’ blood and saliva,” said Ghazi. “If we see evidence of the same genes being elevated in patients, it would be a major first step toward extending such studies to women who undergo early menopause and early infertility.” Ghazi hopes that eventually this work could inform tests for early detection of health impairments triggered by reproductive abnormalities and new treatments or repurposing of existing drugs to treat such age-related diseases. Reference: “Meiotic dysfunction accelerates somatic aging in Caenorhabditis elegans” by Julia A. Loose, Francis R. G. Amrit, Thayjas Patil, Judith L. Yanowitz and Arjumand Ghazi, 29 September 2022, Aging Cell. DOI: 10.1111/acel.13716 The study was funded by the National Institutes of Health.
Researchers have discovered that specific neurons in the thalamus are key in processing signals from the heart and lungs, offering insights into brain-body integration. Credit: SciTechDaily.com Scientists at the UNC School of Medicine, WVU School of Medicine and Swiss Federal Institute of Technology discovered that specific neurons in the brain are actively involved in processing cardiac and respiratory signals. The human brain constantly receives information from the body, specifically from internal organs such as the heart and lungs. This information seldom reaches consciousness but is crucial for maintaining a healthy body and for influencing performance in the brain, including perception, emotion, and cognition. Now, researchers are investigating how exactly the brain processes the incoming stream of information from the heart and lungs, leading to a broader understanding of brain-body integration and the resulting health or disease. Groundbreaking Findings in Neuroscience Publishing their work in the Proceedings of the National Academy of Sciences (PNAS), co-senior authors Vibhor Krishna, MD, associate professor of neurosurgery at the UNC School of Medicine; Ali Rezai, MD, director of the Rockefeller Neuroscience Institute and associate dean of neuroscience at the West Virginia School of Medicine; and Olaf Blanke, MD, PhD, director of the laboratory of cognitive neuroscience at the Swiss Federal Institute of Technology, discovered that specific neurons in the thalamus are actively involved in processing cardiac and respiratory signals. “Each heartbeat and every breath create a rich, incoming stream of sensory information for the human brain,” said Krishna. “However, a deeper understanding of how the brain integrates this information has remained elusive. We have been interested in discovering how the human brain achieves the integration of cardio-respiratory information and whether its breakdown is linked to any disorders of the brain, heart, or lungs observed in the clinic.” Over the years, clinical and research teams collaborated to painstakingly study this integration using an established technique of microelectrode recording during deep brain stimulation surgery. Using a new approach to study single neurons in three different thalamic regions, the researchers were able to observe a direct functional involvement of thalamic and subthalamic neurons in processing cardio-respiratory signals. This information can help to better characterize how subcortical regions of the brain process signals through a functional pathway from internal organs. Advanced Techniques in Neurological Research To complete this work, the research team took advantage of microelectrode recordings during deep brain stimulation for patients undergoing treatment for neurological conditions. The researchers then used these recordings to investigate the activity of single neurons related to cardiac and respiratory functions in three subcortical regions: ventral intermedius nucleus and ventral caudalis nucleus of the thalamus, and the subthalamic nucleus. They found that about 70% of the recorded neurons were modulated by either the heartbeat, the cardiac inter-beat interval, or the respiration. These cardiac and respiratory response patterns varied largely across neurons both in terms of timing and their kind of modulation, the authors wrote. A substantial proportion of these visceral neurons – about 30% – were responsive to more than one of the tested signals, underlining specialization and integration of cardiac and respiratory signals in subthalamic nucleus and thalamic neurons. Implications and Future Directions “We think our work will be significant for several medical specializations, including cardiology, pulmonology, neurology, psychiatry, and psychological research,” Krishna said. Rezai added, “Better understanding of the human brain is the next frontier. And interdisciplinary collaborations between functional neurosurgeons and neuroscientists will enable us to gain an unprecedented window into the inner functioning of the human brain.” Applauding this research as a significant step forward, Nelson Oyesiku, MD, PhD, chair of the UNC Department of Neurosurgery, said, “We understand that the brain maintains homeostasis throughout the body through direct neurological and endocrine regulation. This research reveals that the incoming information from the heart and lungs is processed in the thalamic and subthalamic brain regions, besides other regions, enabling our brain to effectively assume its role in regulating bodily functions.” Reference: “Single neurons in the thalamus and subthalamic nucleus process cardiac and respiratory signals in humans” by Emanuela De Falco, Marco Solcà, Fosco Bernasconi, Mariana Babo-Rebelo, Nicole Young, Francesco Sammartino, Catherine Tallon-Baudry, Vincent Navarro, Ali R. Rezai, Vibhor Krishna and Olaf Blanke, 7 March 2024, Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.2316365121
New research suggests that the orca pods in the northern Pacific, near Japan and Russia, have distinct cultures, dialects, and traditions due to their ice age ancestry, with some pods staying in their refugiums from the ice age rather than migrating. The researchers argue for the classification of orcas into several species or subspecies due to their vast differences in diet and behavior, emphasizing the importance of understanding different orca ecotypes for ecosystem balance and fishing practices. Orcas in North Pacific. Credit: SDU/Olga Filatova Exploring Orca Colonization in the North Pacific The northern Pacific near Japan and Russia is home to several different groups of orcas yet they never interact, hunt different prey, communicate in distinct dialects, and avoid mating with one another. How can this be when they live so close to each other and belong to the same species? Whale expert Olga Filatova from the University of Southern Denmark has dedicated her research to unraveling the mysteries of orca colonization in the northern Pacific. During her tenure at a Moscow University, she led multiple expeditions to study these enigmatic creatures. Currently, she is affiliated with the Marine Biological Research Center at the University of Southern Denmark. Now, some of her latest results have been published. In a recent paper, she and colleagues explore the complex interaction between orca culture and the post-glacial history of their colonization of the North Pacific, showing that the orca pods currently living near Nemuro Strait in northern Japan are descendants of orcas that settled there during the last ice age, around 20,000 years ago. The location was chosen as a refugium by distant ancestors, and their descendants have lived there ever since. “Orcas are conservative and tradition-bound creatures who do not move or change their traditions unless there is a very good reason for it. We see that in this population,” says Olga Filatova. This is the second time she finds an orca refugium from the ice age. The first one is near the Aleutian Islands, some 2500 km away. The pods there are just as conservative and tradition-bound as their Japanese conspecifics and are also descendants of ice age ancestors who found refuge in ice-free waters. Orcas in North Pacific. Credit: SDU/Olga Filatova “When the ice began to retreat again, and orcas and other whales could swim to new ice-free areas, some of them did not follow. They stayed in their refugiums, and they are still living there,” says Olga Filatova. Genetic and Vocal Analysis Reveal Orca Lineage The studies are based on genetic analyses (the researchers took skin biopsies of the animals) and analyses of sounds made by the animals (recorded with underwater microphones). “Orcas in the Nemuro Strait had unusually high genetic diversity, which is typical for glacial refugiums, and their vocal repertoire is very different from the dialects of orcas living to the north off the coast of Kamchatka. Kamchatkan orcas are most likely the descendants of the few pods that migrated west from the central Aleutian refugium, that’s why they are so different”, says Olga Filatova. Orcas’ vocalizations are highly diverse, and no two pods make the same sounds. Therefore, these sounds can be used to identify individuals’ affiliations with families and pods. Orcas are not genetically programmed to produce sound like, for example, a cat is. A cat that grows up among other animals and has never heard another cat will still meow when opening its mouth. In contrast, orcas learn to communicate from their mother or other older family members. Each pod has its own dialect, not spoken by others. “When we combine this with genetic analyses, we get a strong idea of how different orca communities relate to each other,” says Olga Filatova. Orca Migration and Climate Change So far, two ice age refugiums have been discovered, providing us with insight into how orcas may handle current and future climate changes: they will likely move northward as the ice melts, and this colonization may happen in small, individual families or pods rather than in large waves. Orcas in North Pacific. Credit: SDU/Olga Filatova The discovery of the two ice age refugiums not only contributes to knowledge about how orcas survived during the ice age, but it also paints a picture of orcas as very different animals that may not fit neatly into one species. “Many believe that orcas should be divided into several species. I agree – at least into subspecies because they are so different that it doesn’t make sense to talk about one species when discussing their place in the food chain or when allocating quotas to fishermen,” says Olga Filatova. Dietary Preferences and Their Impact on Ecosystems Some orcas eat fish, some only herring, some only mackerel, some only a specific type of salmon. Others only eat marine mammals such as seals, porpoises, and dolphins. Some take a little of everything, and still others live so far out in the open sea that we fundamentally know very little about them. Whether a pod eats fish – and which fish – has a significant impact on the fishing that takes place in their habitat. When a country calculates fishing quotas, it must take into account how many fish are naturally hunted by predators, and since an orca can consume 50-100 kg (110-220 lb) of fish in a day, it greatly affects the quota calculation. If pods eat marine mammals and do not touch fish, this matters if they are to be captured and sold to marine parks, where it is difficult to feed them marine mammals. While marine parks’ popularity is declining worldwide, there is still a large market for orcas in Chinese marine parks. Since there is only one scientifically recognized species of orcas, researchers have resorted to a different form of classification to distinguish between different types of orcas and categorize them into so-called ecotypes. In the northern Pacific, three ecotypes have been defined so far, and in the southern hemisphere, four or five have been described. There are probably more – perhaps up to 20 different ecotypes, according to Olga Filatova. “We need to know the different ecotypes. Orcas are at the top of the food chain, and it affects the entire ecosystem around them what they eat, and where they do it,” says Olga Filatova. In the Danish waters, Skagerrak and Kattegat, close to SDUs Marine Biological Research Center, orcas are occasionally seen. Yet, no one knows if they eat fish or marine mammals – and therefore, also, how they affect the food chain and fishing. “I look forward to learning more about them. Maybe they turn out to belong to a new ecotype,” says Olga Filatova. Pods, families, and clans: Orcas live in families, led by matriarchs. Families gather in close-knit groups, called pods. Clans consist of pods with similar vocal dialects. Ecotypes of orcas: Ecotypes have different dialects, and different habitats, and do not mate with each other. Researchers believe that there may be up to 20 different ecotypes. Known ecotypes in the Northern Pacific: Residents: Close-knit families and pods that stay in the same areas along the coasts. Feed on fish. Transients: Smaller, less cohesive pods that feed on marine mammals. Habitat from Russia to California. Offshore: Live far out in the open sea in groups of 20-200 individuals. Poorly studied. Known ecotypes in the southern Antarctic: Type A: Travel in open waters and seems to feed mostly on minke whales. Type B: Smaller than Type A. Seems to feed mostly on seals. Type C: The smallest. Live in larger groups than the others. Seems to feed mostly on fish. Type D: Range between the 40th and 60th southern latitudes. These are poorly studied. Possible new ecotypes: Groups that feed on fish in the North Atlantic. Groups that feed on marine mammals in the North Atlantic. Groups that feed on penguins and sea lions on the coast of South America. Groups around Gibraltar, feeding on tuna. Groups in the tropics around Hawaii and Gulf of Mexico. Groups around New Zealand, primarily feeding on rays and sharks. Reference: “Genetic and cultural evidence suggests a refugium for killer whales off Japan during the Last Glacial Maximum” by Olga A. Filatova, Ivan D. Fedutin, Ekaterina A. Borisova, Ilya G. Meschersky and Erich Hoyt, 6 July 2023, Marine Mammal Science. DOI: 10.1111/mms.13046
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